You can execute your Silk4NET tests with TFS. Silk4NET does not have any special requirements on TFS and you do not need to change a Silk4NET project to execute it with TFS. To enable the interaction between Silk4NET and the AUT, implement the instructions given in How to: Set Up Your Test Agent to Run Tests that Interact with the Desktop.
To execute Silk4NET tests, perform the following steps, which might vary slightly depending on your actual setup and the used versions of Visual Studio and TFS. For additional information on the requirements and the configuration of Visual Studio and TFS, refer to the documentation of these products: